By Jennifer Copley (Last Updated 30 March 2012)
Some evidence suggests that inositol abnormalities may be a factor in autism. For example, Seelan et al. (2007) found altered myo-inositol levels in those with autistic spectrum disorders.
According to Levine et al. (1997): “Inositol is a precursor of the second messenger for some serotonin receptors, and has been reported effective in depression, panic disorder and obsessive-compulsive disorder. However a controlled double-blind crossover trial of inositol 200 mg/kg per day showed no benefit in 9 children with autism.”
Overall, what little research has been conducted thus far suggests that inositol is probably not useful in treating most autistic symptoms, but may provide benefits when used to treat unpleasant conditions that often accompany autism, such as panic attacks, obsessive-compulsive disorder, and depression.
Other Autism Supplements
For more on the effectiveness of other supplements for treating autistic spectrum disorders, see the main Autism Supplements page. For a full list of articles on autism and Asperger’s syndrome, visit the main Autistic Spectrum Disorders page.
Always consult a qualified medical practitioner before taking supplements or giving them to your child. Many supplements are toxic at certain doses and may interact with some medications or create problems for people with certain medical conditions.
This article is not intended as a substitute for medical consultation or care. Health concerns should be referred to a doctor.
- Levine, J.; Aviram, A.; Holan, A.; Ring, A.; Barak, Y.; & Belmaker, R.H. (1997). “Inositol Treatment of Autism.” Journal of Neural Transmission, 104(2-3), pp. 307-310.
- Levine, J. (1997). “Controlled Trials of Inositol in Psychiatry.” European Neuropsychopharmacology, 7(2), pp. 147-155.
- Seelan, R.S.; Pisano, M.M.; Greene, R.M.; Casanova, M.F.; & Parthasarathy, R.N. (2011). Differential Methylation of the Gene Encoding Myo-Inositol 3-Phosphate Synthase (Isyna1) in Rat Tissues.” Epigenomics, 3(1), pp. 111–124.